Antibiotics

Product Details:

Pharmacotherapeutic group: Second generation cephalosporins ATC code: J01DC02 Cefuroxime is a bactericidal cephalosporin antibiotic which is resistant to most beta-lactamases and is active against a wide range of Grampositive and Gram-negative organisms. Cefuroxime inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs). This in turn inhibits the final trans-peptidation step of peptidoglycan synthesis, essential for bacterial cell wall synthesis. Eventually sensitive bacteria get lysed due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases), while cell wall assembly is arrested. Pharmacokinetic Properties Absorption and Distribution After intramuscular (IM) injection of a 750 mg dose of cefuroxime to normal volunteers, the mean peak serum concentration was 27 mcg/mL and occurred at approximately 45 minutes (range, 15 to 60 minutes). Following intravenous (IV) doses of 750 mg and 1.5 g, serum concentrations were approximately 50 and 100 mcg/mL, respectively, at 15 minutes. Therapeutic serum concentrations of 2 mcg/mL or more were maintained for 5.3 hours and 8 hours or more, respectively. There was no evidence of cefuroxime accumulation in the serum following IV administration of 1.5 g doses every 8 hours to normal volunteers. Cefuroxime is detectable in therapeutic concentrations in pleural fluid, joint fluid, bile, sputum, bone, aqueous humor, and cerebrospinal fluid (CSF) of adults and pediatric patients with meningitis. Cefuroxime is approximately 50% bound to the serum protein. Metabolism and Excretion The serum half-life after either IM or IV injections is approximately 80 minutes and is prolonged in neonates and patients with renal impairment. Approximately 89% of a dose of cefuroxime is excreted unchanged by glomerular filtration and renal tubular excretion by the kidneys over an 8-hour period, resulting in high urinary concentrations. A small amount of cefuroxime is excreted in bile. Following the IM administration of a 750 mg single dose, urinary concentrations averaged 1,300 mcg/mL during the first 8 hours. Intravenous doses of 750 mg and 1.5 g produced urinary levels averaging 1,150 and 2,500 mcg/mL, respectively, during the first 8- hour period.
The concomitant oral administration of probenecid with cefuroxime slows tubular secretion, decreases renal clearance by approximately 40%, increases the peak serum level by approximately 30%, and increases the serum half-life by approximately 30%.

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PRODUCT INTRODUCTION Colistin 2Million IU Injection is an antibiotic that fights bacteria. It is used to treat severe bacterial infections of the body. It is commonly used for critically ill patients admitted to the hospital.

Colistin 2Million IU Injection is given under the supervision of a healthcare professional. You should not self-administer this medicine at home. The dose and duration will be decided by your doctor based on the severity and type of infection you have. Get the injection regularly for as long as your doctor has prescribed to get maximum benefits.

Some people may develop side effects like stomach upset, slurred speech, dizziness, vertigo, fever, rash, and paresthesia. These side effects are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or do not go away.

Before starting treatment with this medicine, you should tell the doctor if you are allergic to any antibiotic or have any liver or kidney problems. Pregnant or breastfeeding mothers should consult their doctor before using it. Your doctor may get regular blood tests done to monitor kidney function and the level of the medicine in your blood.USES OF COLISTIN POWDER FOR INJECTION

• Severe bacterial infections

BENEFITS OF COLISTIN POWDER FOR INJECTIONIn Severe bacterial infectionsColistin 2Million IU Injection is an antibiotic that works by killing bacteria which can cause serious infections. It is a versatile medicine used to treat many different types of bacterial infections. This medicine is usually given as an injection by a doctor or nurse and should not be self-administered at home.

This medicine usually makes you feel better very quickly but you should continue taking it as prescribed even when you feel better to make sure that all bacteria are killed and do not become resistant.SIDE EFFECTS OF COLISTIN POWDER FOR INJECTIONMost side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you're worried about themCommon side effects of Colistin

• Upset stomach
• Rash
• Paresthesia (tingling or pricking sensation)
• Dizziness
• Slurred speech
• Vertigo
• Fever

HOW TO USE COLISTIN POWDER FOR INJECTIONYour doctor or nurse will give you this medicine. Kindly do not self administer.HOW COLISTIN POWDER FOR INJECTION WORKSColistin 2Million IU Injection is an antibiotic. It kills bacteria by destroying the bacterial cell membrane.

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Azicip 500 Tablet is an antibiotic used to treat various types of bacterial infections of the respiratory tract, ear, nose, throat, lungs, skin, and eye in adults and children. It is also effective in typhoid fever and some sexually transmitted diseases like gonorrhea. 

 

 

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Levoquin 500mg Tablet is an antibiotic, used in the treatment of bacterial infections. It is also used in treating infections of the urinary tract, nose, throat, skin and lungs (pneumonia). It cures the infection by stopping the further growth of the causative microorganisms.

Levoquin 500mg Tablet should be used in the dose and duration as advised by your doctor. It may be taken with or without food, preferably at a fixed time. Avoid skipping any doses and finish the full course of treatment even if you feel better. Do not take a double dose to make up for a missed dose. Simply take the next dose as planned.

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Treats Lower respiratory tract infections, ENT infections, and genito-urinary infections
Treats Lower respiratory tract infections, ENT infections, and genito-urinary infections..

Product Details:

Suprava TZ 1000 mg/125 mg Injection is a combination medicine. It is prescribed to treat various types of bacterial infections. It fights against the microorganisms to prevent their growth and further spread of the infection.

Suprava TZ 1000 mg/125 mg Injection should only be administered under the supervision of a healthcare professional. Do not miss any scheduled appointments for taking this medicine. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine.

Some common side effects of this medicine are nausea, vomiting, diarrhea, indigestion, etc. If any of the side effects get aggravated, you must consult your doctor immediately. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.

Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Pregnant or breastfeeding women should also consult with their doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. You must take adequate rest for a faster recovery, also take a healthy diet and drink plenty of water. Your doctor may ask for a few laboratory and diagnostic tests to know the effects of the medicine on your body.

Product Details:

Pharmacotherapeutic group: Second generation cephalosporins ATC code: J01DC02 Cefuroxime is a bactericidal cephalosporin antibiotic which is resistant to most beta-lactamases and is active against a wide range of Grampositive and Gram-negative organisms. Cefuroxime inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs). This in turn inhibits the final trans-peptidation step of peptidoglycan synthesis, essential for bacterial cell wall synthesis. Eventually sensitive bacteria get lysed due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases), while cell wall assembly is arrested. Pharmacokinetic Properties Absorption and Distribution After intramuscular (IM) injection of a 750 mg dose of cefuroxime to normal volunteers, the mean peak serum concentration was 27 mcg/mL and occurred at approximately 45 minutes (range, 15 to 60 minutes). Following intravenous (IV) doses of 750 mg and 1.5 g, serum concentrations were approximately 50 and 100 mcg/mL, respectively, at 15 minutes. Therapeutic serum concentrations of 2 mcg/mL or more were maintained for 5.3 hours and 8 hours or more, respectively. There was no evidence of cefuroxime accumulation in the serum following IV administration of 1.5 g doses every 8 hours to normal volunteers. Cefuroxime is detectable in therapeutic concentrations in pleural fluid, joint fluid, bile, sputum, bone, aqueous humor, and cerebrospinal fluid (CSF) of adults and pediatric patients with meningitis. Cefuroxime is approximately 50% bound to the serum protein. Metabolism and Excretion The serum half-life after either IM or IV injections is approximately 80 minutes and is prolonged in neonates and patients with renal impairment. Approximately 89% of a dose of cefuroxime is excreted unchanged by glomerular filtration and renal tubular excretion by the kidneys over an 8-hour period, resulting in high urinary concentrations. A small amount of cefuroxime is excreted in bile. Following the IM administration of a 750 mg single dose, urinary concentrations averaged 1,300 mcg/mL during the first 8 hours. Intravenous doses of 750 mg and 1.5 g produced urinary levels averaging 1,150 and 2,500 mcg/mL, respectively, during the first 8- hour period.
The concomitant oral administration of probenecid with cefuroxime slows tubular secretion, decreases renal clearance by approximately 40%, increases the peak serum level by approximately 30%, and increases the serum half-life by approximately 30%.